Osteoporosis

Osteoporosis is a systemic skeletal disease characterized by a reduction of bone density and altred bone quality, with increased fracture risk.


A systemic skeletal disease characterized by:

  • Reduction of bone density.
  • Altered bone quality.
  • Increased fracture risk .

The number

In developed countries, the lifetime risk for osteoporotic fractures at the wrist, hip or spine is 30% to 40%, very close to that for coronary heart disease.


An age-related disease

Osteoporosis is an age related disease and becomes more common in advanced age.


Meaning of fractures

Elderly suffering with femoral fractures die within a year (15-25%) or become dependent (50%). A single vertebral fracture doubles the risk of subsequent femoral fracture within a year. Multiple vertebral fractures impair patients’ quality of life and increase mortality.


Some things

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Socioeconomic burden:

  • Inhospital stay
  • Rehabiltation costs
  • Loss of indipendence
  • Caregiver burden
  • Increased mortality


Novaicos aims to reduce the fracture incidence with an innovative pharmacological approach, is developing a new biological drug, biocompatible and modulable, reversible and efficacious.


ICOS/ICOSL endogenous pathway

Discovered by Prof. Dianzani in 2000
Mediates T cell/APC interaction


ICOS-Fc work

ICOS-Fc inhibits bone resorpition and allows bone formation.


ICOS-Fc inhibit osteoclast formation and activity in vitro

ICOS-Fc directly inhibits the bone resorbing cells (osteoclasts) without toxic effect.


ICOS-Fc activity in models of bone erosion

ICOS-Fc is able to restore bone structure in vivo in different mice models of osteoporosis.


On Target

selective inhibits resorbing osteoclats


On Time

quick wash out (20 days) allows bone remodelling


Scientific Road Map

  • A - Pre clinical data on osteoporosis completed
  • B - Development of new formulations
  • C - GMP Compounr obtained
  • D - Phase 1 Clinical Study